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This reduction was driven primarily by fewer nonfatal strokes (39% reduction) and nonfatal heart attacks (26% reduction), establishing semaglutide's role in cardiovascular protection for diabetic patients

5 Exercise as a modulator of musclevasculature interactions 5.1 Exercise-induced signaling pathways improving endothelial and muscle function Exercise constitutes a robust, pleiotropic stimulus that orchestrates adaptive responses in both skeletal muscle and the vascular endothelium, thereby facilitating the restoration and preservation of the musclevasculature axis, which tends to deteriorate with advancing age

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