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The relationship between mast cells, histamine, and the nervous system is a bidirectional vicious cycle

What the Clinical Data Shows Honesty about the evidence is what keeps this kind of article credible, so the record deserves a clear look

10.1016/0091-3057(93)90126-E 97 TalsaniaT.AniniY.SiuS.DruckerD

Outcomes were similar to the other STEP trials, with the co-primary outcomes being percentage change from baseline in body weight and the percentage of patients achieving a 5% or greater weight reduction