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A significant influx of undigested proteins into the distal intestine as a result of impaired protein absorption encourages the overgrowth of proteolytic bacteria (Sorensen, 1965), which in turn causes an increase in protein fermentation clinically manifesting in protein-energy wasting, cardiovascular diseases, neurological syndromes, and CKD progression (Figure 3)

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Preliminary trials suggest a reduction in alcohol craving and relapse by modulating brain reward circuits

Hypertension 48 , 10661071 (2006)