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Emerging research demonstrates that the mitochondrial quality control (MQC) system maintains cellular homeostasis through coordinated processes including mitochondrial biogenesis, mitophagy, and mitochondrial dynamics (fission/fusion)

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SIRT1 stimulates the deacetylation and functional enhancement of PGC-1-a pivotal controller of mitochondrial biosynthesis and cellular antioxidant capacity-while p53 concurrently modulates SLC7A11 expression, a core subunit of the cystine/glutamate antiporter essential for glutathione production (117)

Regul Pept 134:149157 Setty AR, Curhan G, Choi HK (2007) Obesity, waist circumference, weight change, and the risk of psoriasis in women: Nurses Health Study II