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Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression

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Starting with smaller doses and increasing them over time can minimize side effects.

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A study analysed health records from over 1.2 million individuals with type 2 diabetes and found that those using GLP-1 medications had a lower incidence of colorectal cancer compared to those on other antidiabetic treatments