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Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease

Because mature IR exists as a stable dimer with two site-1 and two site-2 binding surfaces, up to four insulin molecules can bind a single IR dimer, inducing a symmetric T-shaped active conformation( 43 ) (Fig

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