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These were further confirmed in another study of murine eosinophilic asthma, whereby apigenin (25 mg/kg) reduced airway hyperresponsiveness, airway inflammation, and Th2 cytokines IL-4, IL-5, IL-13, eosinophil derived neurotoxin, and eosinophil peroxidase [138]

GSH helps maintain mitochondrial health, improving energy production in neurons

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This compound activates c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2 and induces apoptosis

The foundational mechanism papers from the Washington State University lab that described how Dihexa works were retracted in April 2025 following a misconduct finding, with a third paper under an Expression of Concern since 2021