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While the most pronounced weight loss with GLP-1RA therapy tends to occur within the first 6 months of treatment, continued use is generally associated with maintenance or further incremental weight loss

Step-by-Step Mechanism of Action Activation of GLP1 receptors Semaglutide binds to GLP-1 receptors on pancreatic -cells, -cells, brain satiety centers, and gastrointestinal tissue

The same mechanism that reduces food-seeking behaviour may similarly dampen responses to alcohol and drugs