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This reflects the chronic biology of obesity rather than a failure of the individual and reinforces that long-term treatment is often needed

GLP-1 therapy is generally not recommended during breastfeeding due to theoretical concerns about infant exposure and caloric restriction during lactation

5,6,7 GLP-1 is a peptide produced by the cleavage of proglucagon, mainly synthesized in the intestinal mucosal L-cells, pancreatic islet -cells, and neurons in the nucleus of the solitary tract

GLP-1R agonists have reducing neuroinflammation and oxidative stress, neurotrophic effects, decreasing A deposition and tau hyperphosphorylation in AD models, which may be a potential drug for the treatment of AD

7 As the first approved dual agonist targeting both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, tirzepatide demonstrated weight loss exceeding 20% in its pivotal trials, establishing a new therapeutic ceiling