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Smoking is the single greatest modifiable risk factor for impaired fracture healing

It is the difference between repairing tissue in an inflamed environment versus repairing tissue in a calm one

Its needed for: Red blood cell formation Nervous system function DNA synthesis Energy production Signs and Symptoms of B12 Deficiency Spotting vitamin B12 deficiency signs early is vital

For topical use, transient local reactions redness, stinging, burning, or itch are the expected category and are exactly what the ongoing Phase 2 trial is set up to measure (NCT07437586)

Exploratory endpoints included achieving 15% and 20% weight loss, and patient-reported outcomes assessed using the SF-36 v2.0 and the Three-Factor Eating Questionnaire (TFEQ-R18 v2)