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10.15171/jcs.2015.030 118 ShibataK.GrossC

This guide explains what we currently know about GLP1 medication and menopause including weight gain, HRT, muscle loss, fatigue, side effects and long-term weight maintenance

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The Phase 2 trial enrolled participants with obesity and evaluated multiple dose levels over 48 weeks: 1 mg dose: 8.7% average body weight reduction 4 mg dose (escalated from 2 mg): 17.1% average body weight reduction 8 mg dose (escalated from 2 mg): 22.8% average body weight reduction 12 mg dose (escalated from 2 mg): 24.2% average body weight reduction Placebo: 2.1% average body weight reduction Those Phase 2 numbers were striking enough

IGF-1 and insulin share similar signaling pathways, particularly the PI3K and AKT pathways