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Furthermore, tumor core regions display low glutamine levels compared to the periphery, and this regional glutamine deficiency in tumors promotes de-differentiation through the inhibition of histone demethylation [40,43]

We and others have demonstrated that GLP-1R signalling elevated ATP levels 38, 39 , strengthening the hypothesis that the incretin hormone may promote -cell function through regulation of energy metabolism, especially considering the central role that ATP generation and an increase in ATP/ADP ratio play during GSIS

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