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Once the acylcarnitine is formed, a specialized carrier protein called Carnitine-Acylcarnitine Translocase (CACT) shuttles it across the inner mitochondrial membrane and into the mitochondrial matrix

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Not all biological, physical, or chemical factors that may promote melanogenesis are known, neither are all the factors that may influence the size, distribution, or intensity of areas of oral pigmentation

Brain imaging studies (eg, cranial ultrasound, brain MRI) may show cystic lesions in glutaric aciduria type II or basal ganglia involvement in mitochondrial disorders that may be associated with secondary carnitine deficiency