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Dietary adjustments, such as avoiding high-fat and high-fiber foods, can help manage diarrhea caused by Ozempic while also reducing fermentation that leads to sulfur burps

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Downregulation or deficiency of pyruvate kinase leads to ATP depletion which in turn affects cell viability as well as accumulation of the glycolytic intermediates (2,3-diphosphoglycerate (2,3-DPG) that eventually leads to impaired glycolytic flux 46

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All trials were blinded except one that was not blinded and the authors acknowledged that this prevented them from determining the independent effect of orlistat