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Interestingly, VCAM-1a protein expressed by endothelial cells in the BBB that is involved in peripheral immune cell recruitmentexpression increases in the aged brain, and the application of anti-VCAM-1 antibodies reduces microglial reactivity and improves memory and learning in aged (19-month-old) mice (Yousef et al., 2019)

KLOW is therefore not a single mechanism

non-responding individuals

The study investigated the randomized treatment effect of low dose aspirin on incident diabetes and fasting plasma glucose (FPG) levels among older adults

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