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After the initial 36 weeks, participants lost 21.1% of their body weight After the following 52 weeks, the tirzepatide group lost another 6.7% of their body weight, while the placebo group regained 14.8% Through the 88-week study, the tirzepatide group lost 26% of their body weight Tirzepatide had a similar safety profile in SURMOUNT-3 and SURMOUNT-4 as its previous trials, most commonly citing mild-moderate gastrointestinal issues
When blood glucose levels rise after eating, Ozempic: Stimulates insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppresses glucagon release , reducing hepatic glucose production Slows gastric emptying , which helps moderate post-meal blood sugar spikes Reduces appetite via central nervous system pathways This multi-faceted approach makes Ozempic effective in improving glycaemic control (as measured by HbA1c levels)
In some cases, maintaining the current dose for a longer period or implementing a more gradual titration schedule may be appropriate
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