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It not only has antioxidant effects but also increases NRF2 levels, clears peroxynitrite, inhibits Fe 2 transport, and binds to protein thiol groups [430]

mtDNA internalization, or receptor-mediated activation of immune response as DAMP, triggers sterile inflammation and amplifies cytokine and type I interferon signaling, thereby establishing feed-forward loops of mitochondrial dysfunction, immune activation, and secondary mtDNA release

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Calcium-Deficiency during Pregnancy Affects Insulin Resistance in Offspring