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Its key feature lies in the competitive utilization of the same substrate by iNOS (also known as Nos2) and Arg1: the former generates NO and is closely associated with pro-inflammatory effects, whereas the latter produces ornithine and polyamines and participates in tissue repair and immune regulation ( Under classical pro-inflammatory stimulation (such as LPS/IFN-), iNOS expression is upregulated and catalyzes the conversion of Arg into NO and citrulline

In contrast, the production of bile acids by gut bacteria can function as signaling molecules to regulate G proteincoupled bile acid receptor 1 (TGR5) and augment energy metabolism in muscles, while also promoting the stimulation of thyroid hormone [70]

Glutathione is one of the essential antioxidants that prevent the signs of aging

1998;275(5 Pt 1):C1365-1371

Dermal lymphatic dilation in a mouse model of alopecia areata