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Empagliflozin activated SIRT3-mediated autophagic signaling pathways via AMPK/Beclin1 and autophagosome membrane elongation, which induced the formation of myocardial autophagosomes and reduced cardiac pathological remodeling, ultimately alleviating damage to the cardiac structure [114]

Neurorestoratives act on the machinery and the accumulated state of the tissue, including the energy supply of neurons, the burden of damaged proteins, the level of inflammation, and the health of small blood vessels

Future research and clinical implications Current studies focus on short-term efficacy, but gaps persist regarding the impact on reproductive health, hormonal balance, and bone density over prolonged use

Lipparini, F

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