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When used as part of a broader weight management strategy, including diet, exercise, and lifestyle adjustments, these medications have been shown to be safe and effective for extended periods, with mild side effects like nausea typically diminishing over time

The effect held after washout, with off-medication scores of 17.7 versus 20.6

Abstract Objective: Having demonstrated short-term weight loss with liraglutide in this group of obese adults, we now evaluate safety/tolerability (primary outcome) and long-term efficacy for sustaining weight loss (secondary outcome) over 2 years

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