Their organization into broad categories represents an interconnected hierarchy where the primary hallmarks reflect macromolecular damage (i.e., genome, proteome, organelles) which lead to antagonistic hallmarks, e.g., response to the damage
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120 These advanced technologies have mapped the precise spatial zonation of immune responses, revealing how distinct subpopulations of hepatic non-parenchymal cells, such as specific lipid-associated macrophages localized at fibrotic zones or bile ducts, uniquely respond to gut-derived metabolic signals
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