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Mitochondrial transfer mediated by mesenchymal stem cells (MSCs) could restore the mitochondrial pool of neurons and inhibit ferroptosis, 951 providing a promising clinical translational strategy for ferroptosis-related central nervous system diseases based on stem cell-mediated mitochondrial therapy

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Due to their poor stability and low bioavailability, it is difficult to develop KEAP1-NRF2 PPIs as neurodegenerative drugs

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