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Importantly, no nausea was experienced during any of the infusions, including the combined PYY 3-36 and GLP-1 7-36 amide infusion

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Lancet 2008;371:1753-60.PubMed 48

the magnitude of HbA1c change in this non-diabetic population was modest, as would be expected Fasting insulin levels decreased, indicating improved insulin sensitivity Triglyceride and lipid profiles showed favourable changes, which may reduce cardiometabolic risk Waist circumference was substantially reduced, reflecting a decrease in visceral (abdominal) adiposity These findings are particularly relevant given that excess visceral fat is strongly associated with type 2 diabetes, cardiovascular disease, and metabolic syndrome