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It seems that chemotherapy regimens (drug or combination of drugs administered and dosing), methods of pain assessment and the individual patient characteristics (presence of comorbidities associated with increased risk of neuropathy, such as diabetes, depression, insomnia or genetic particularities) are some of the several factors that may influence on the onset of CIPN and the severity of symptoms

(2019) Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

A common feature is the presence of transepidermal elimination of nests of melanocytes