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However, the mechanisms involved in the release of peptide hormones, GLP-1 and PYY in response to TGR5 activation by bile acids and the effect of H 2 S on bile acid-induced release of GLP-1 and PYY are unclear

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Indeed, in both studies, the highest frequency of TEAEs was in the normal function groups, possibly owing to the smaller sample sizes in the more severe impairment groups, or alternatively because participants with more serious health concerns, such as those with severe renal or hepatic impairment, may be less likely to notice or report mild or moderate TEAEs, as observed in populations with cancer [21]

Meanwhile, histological examination by H&E staining further showed that 261.90 and 390.00 mg/kg TAs could improve liver structure