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Description

The third family, IGF-1 LR3, skips the GH-signaling step entirely, binding directly to the IGF-1 receptor on muscle tissue and activating the PI3K/Akt and MAPK pathways tied to cell growth

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doi: 10.1016/j.ejim.2007.04.016 343

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437 However, the combination of nifedipine and supplemental oxygen did not provide significant advantages over supplemental oxygen alone

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