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Patients and clinicians should be aware that reflux-type symptoms are biologically plausible and have been reported in trial settings for this drug class, even if a definitive causal link has not been formally established for retatrutide specifically

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Anxiety considerations and fatigue are among the commonly reported experiences at higher doses

In recent years, there has been a high level of evidence regarding the combined use of topical calcineurin inhibitors, such as tacrolimus ointment and pimecrolimus ointment, and UV light therapy to vitiligo49, 50

doi:10.1001/jama.2024.10816