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The global resolutions were calculated according to the gold standard Fourier shell correlation (GSFSC) criterion of 0.143

8 weeks: ~2 vials 12 weeks: ~23 vials 16 weeks: ~3 vials Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 8 weeks (once daily): ~56 syringes 16 weeks (once daily): ~112 syringes Bacteriostatic Water (10 mL bottles) Use ~3.0 mL per 10 mg vial for reconstitution

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However, successful clinical translation will require addressing persistent challenges, including biosafety, biodistribution, tumor heterogeneity, and large-scale manufacturability