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They stimulate insulin secretion and inhibit glucagon secretion by elevating endogenous GLP-1 concentrations without an intrinsic hypoglycaemia risk

Asiatic acid has evidence of various prerequisites in laboratory animals in diseases such as hypertension, neurodegenerative disorders, diabetes, and cancer

Restraints High Treatment Costs and Limited Affordability A major obstacle is affordability, as GLP-1 analogue therapies are substantially more costly than traditional diabetes treatments

Lipodystrophy includes lipohypertrophy (thickening of adipose tissue) and lipoatrophy (thinning of adipose tissue) and may affect insulin absorption [see Dosage and Administration (2.1)]

Turrens JF (2003) Mitochondrial formation of reactive oxygen species