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Lcarnitine is produced in the liver and kidneys and stored mainly in the most active metabolic tissue such as the skeletal muscles, heart, brain, and sperm

These allosteric effects can be modulated through the action of carnitine acetyltransferase (CAT), a mitochondrial isoenzyme that transfers the acetyl groups from acetyl-CoA to carnitine, forming acetylcarnitine

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Ozempic) and chronic weight management (Wegovy)

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Proof-of-concept gene editing for the murine model of inducible arginase-1 deficiency