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published evidence that BPH is caused by failure in the spermatic venous drainage system resulting in increased hydrostatic pressure and local testosterone levels elevated more than 100-fold above serum levels

Novel microbiome-targeted, neuromodulatory, and antifibrotic therapies are emerging as promising mechanism-based options

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Surgical resection of lesions is a common treatment, but beyond accessibility issues in low-resource settings, it has limited efficacy, and rates of lesion recurrence, repetitive surgical procedures and pain persistence are high