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Since both medications influence GLP-1 receptors, there is a plausibility of increased side effects like gastrointestinal problems or a higher risk of low blood sugar levels

On May 1, 2025, Eli Lilly announced that it withdrew its FDA application for Zepbound (tirzepatide) for the treatment of HFpEF in patients with obesity, stating that the FDA requires an additional confirmatory trial to support the application

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Having confidence in ones ability is not only important when things go well, but also when things aren't going well, such as needing to take a different approach or trying several times until something works