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However, GS-R mice retained a considerable amount of hydrophilic bile acids: -muricholic acid (MCA), MCA, and ursodeoxycholic acid (UDCA) in their bile (25%), but less hydrophobic DCA

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The glucagon arm is the third lever: rather than only reducing energy intake through appetite, glucagon agonism raises energy expenditure and pushes the liver to mobilize stored fat

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