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3.1 Biological Interpretation of GSH and GSSG Concentrations A decrease in GSH can result from reduced synthesis, oxidation, conjugation, protein S-glutathionylation, export, degradation, or loss of cellular integrity

[3] Because MK-677 activates the ghrelin receptor, it is accurately described as a ghrelin receptor agonist or ghrelin mimetic. At the cellular level, GHSR1a is a Gq-coupled receptor: activation drives phospholipase C, inositol trisphosphate, and a rise in intracellular calcium in pituitary somatotrophs, which triggers GH release