Today, this rigid dichotomy has been dismantled, and increasing evidence shows that many metabolic hormones have a profound impact on the brain reward function
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(Lond.) 95 , 719724 (1998)
This results in reduced urinary excretion of carnitine, low serum carnitine levels, and a range of metabolic disorders, including cardiomyopathy and hypoketotic hypoglycemia (De Biase et al., 2012
Mechanisms of contact sensitization offer insights into the role of barrier defects vs