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In EAT the drug reduced FABP4 and perilipin 1 ( PLIN1 ), but not ADIPOQ expression and on SAT it reduced PPAR coactivator 1-alpha ( PGC1) expression

While it dramatically reduces appetite, it doesn't address psychological relationships with food or eating behaviors driven by factors other than hunger

Its sequence AcNlecyclo[AspHisDPheArgTrpLys]NH incorporates a norleucine substitution, a Dphenylalanine substitution, and a lactam bridge that cyclises the molecule, conferring markedly greater stability and resistance to enzymatic degradation than the native linear hormone

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