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This approval is a significant decision because people living with excess weight or obesity and established cardiovascular disease and without diabetes have never had an FDA-approved treatment option that lowers weight and reduces the likelihood of another cardiovascular event, said A Michael Lincoff (Cleveland Clinic, Cleveland, USA) and the lead study author of the SELECT outcomes trial

The syndrome encompasses both individuals at risk for ASCVD due to the presence of metabolic risk factors or CKD, and those with established CVD complicated by metabolic or kidney dysfunction [146]

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Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1

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