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Side Effects of Tirzepatide | Verdict Tirzepatide is a novel, dual GIP and GLP-1 receptor agonist that has shown unprecedented efficacy in the management of T2D

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fatigue that worsens over days may reflect cumulative dietary changes or electrolyte shifts

In several cases, durable metabolic benefits appear to require co-administration with specific dietary substrates or prebiotics, such as inulin-based synbiotics or chemically modified resistant starch, highlighting that both microbial composition and nutrient context are critical for colonization stability and functional output (Wang et al., 2025)