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S1PR2, sphingosine-1-phosphate receptor 2

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Glutathione helps modulate the body's inflammatory response by inhibiting the production of pro-inflammatory cytokines, thereby reducing chronic inflammation and associated health risks

different CSC subclones within the same tumor exhibit distinct gene expression profiles, metabolic dependencies, and responses to therapy, contributing to overall tumor heterogeneity

This dual mechanism is why the SURPASS and SURMOUNT clinical trials showed unprecedented results