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Dihexa(PNB-0408), an oligopeptide drug, is an orally active and blood-brain barrier-permeable analog of angiotensin IV

The sealed crimped stopper maintains sterility and benzyl alcohol remains stable across this range

36 Moreover, after pathological examination of brains from the Mayo clinic, of the brains exhibiting signs of chronic disease, 33% of patients had participated in contact sports

The thiol group further stabilizes the complex through additional hydrogen bonds within the pocket

This effect has been observed in aging and different pathologies: neurodegenerative diseases, metabolic disorders and cancer (Rass et al., 2007