This means its structure must precisely target and activate three different receptors: GIP, GLP-1, and glucagon
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In January 2024, the FDA announced it was investigating semaglutide for several potential safety signals, including blood clots, alongside hair loss, aspiration risk, and suicidal ideation
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Clinical trial data showed participants experiencing severe, persistent vomiting lasting weeks (a hallmark symptom of gastroparesis), yet this information was characterized as temporary gastrointestinal adverse events in public communications