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The recurrence of illness (ROI) index is a key factor in major depression that indicates increasing immune-linked neurotoxicity and vulnerability to suicidal behaviors

when mitochondria have extensive and severe damage, excessively activated mitophagy will further exacerbate cellular energy crisis and functional failure

PMID: 16099219[PubMed Reference] Sosne G, Qiu P, Goldstein AL, Wheater M

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