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Chemotherapeutic regimens, such as anthracycline-based combinations with ifosfamide, are associated with significant toxicity and rapid development of resistance, offering limited survival advantage ( Notably, in this case, subtotal resection was performed due to dense adhesion between the tumor and spinal nerve root

Glycyl-L-histidyl-L-lysine (GHK) is a naturally occurring tripeptide found in human plasma that has a very high affinity for copper ions (Cu+)

HamzehNLiLBarkesBHuangJCanonoBGillespieMet al

It signals blood-vessel cells to sprout new capillaries into the repair area (angiogenic signaling) and stabilizes tissue barriers so new tissue holds instead of breaking down. Without blood flow to the dermis, GHK-Cu has the signal but the raw material never reaches the work

Owing to the overproduced H 2 O 2 and GSH in tumor cells, TeNW can selectively eliminate cancer cells while normal cells survive (Figure 1J)