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Plasma, urine and liver tissues were profiled using untargeted MS methods, which detected both primary and secondary bile acids

As the c-Jun/ATF2 heterodimer induces transcription of many genes such as Cyclin D1 , Cyclin A , c-Jun and Atf3 , 37 changes in JNK activation most likely contributes along with ERK1/2 signaling alterations to the delay in G1-to-S phase progression in Gstp1/2 / mice

Ideally, the body will have higher amounts of GSH (active glutathione), which can readily neutralize free radicals that damage cells ( 1 , 2 )

Data post-processing was conducted using R scripts

When both nutrients are deficient, B12 should be initiated before or alongside folate to avoid worsening neurological symptoms