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Effects on gene expression Transcriptomic studies in cells exposed to GHK-Cu have reported broad changes in gene expression affecting genes involved in collagen and matrix synthesis, antioxidant defense (including superoxide dismutase, catalase, and others), DNA repair, immune signaling, and cellular metabolism

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Studies have demonstrated that individuals with T2DM exhibit reduced glucose oxidation and increased reliance on lipid metabolism, which may exacerbate insulin resistance and contribute to mitochondrial dysfunction (37)

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