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Although receptor desensitization is crucial to the functioning of many ligand-gated ion channels in vivo , the molecular basis of this important process has until now defied analysis

Escherichia coli alpha-hemolysin HlyA induces host cell polarity changes, epithelial barrier dysfunction and cell detachment in human colon carcinoma Caco-2 cell model via PTEN-dependent dysregulation of cell junctions