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The FDA flagged a number of items that it claims are misleading, including theres a lack of clinical data to support the superiority of Ozempic relative to other GLP-1s, and the letter takes aim at small details in the ad, from comedic devices to the color of shirts

A 2023 analysis published in JAMA Network Open found that high out-of-pocket costs for GLP-1 receptor agonists were the primary driver of treatment discontinuation within the first 12 months, with 42.1% of commercially insured patients stopping therapy by month 12

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This could explain the various and efficient antioxidant systems at muscle level including various isoenzymes of Superoxide dismutase (SOD), GPx and catalase, high activity of GSH-dependent enzymes and a strong ability to synthesize new GSH [24,50]