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DATS also inhibited LPS-induced NF-B-dependent expression of COX-2, iNOS, tumor necrosis factor- (TNF-), and interleukin-1 (IL-1) (37)

Although many animal models of DS have been constructed, no model animal can completely trace the symptoms occurring in humans

Topical serums work at the skin surface and in the uppermost layers of the dermis, which means they address pigmentation locally rather than systemically

Given its critical importance, vitamin B9 deficiency is associated with severe neurological complications, such as spinal cord and peripheral nerve disease, dementia, organic brain syndrome, and pyramidal tract damage (, , )

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