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Many people regain the weight they lose if they stop taking the medication

For compounded tirzepatide sublingual liquid, the starting frequency is once daily

Some plans limit coverage to 12 months

4,5,6 Since 2008, the Food and Drug Administration (FDA) and European Medicines Agency have required that new T2D pharmacotherapies undergo rigorous cardiovascular safety clinical trials using hard cardiovascular endpoints and more stringent statistical review

[2] Patients should also seek medical review if constipation significantly impacts quality of life or if they find themselves increasingly reliant on stimulant laxatives