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In AD transgenic mice, hippocampal mitochondria show reduced Complex I activity, elevated reactive oxygen species, and fragmented morphology even before plaque formation

PK parameters analyzed included maximum plasma concentration of LY(C max ), area under the concentration versus time curve from time zero to innity (AUC 0-N ), time of maximum observed drug concentration (t max ) of LY, half-life, apparent clearance, and apparent volume of distribution of LY3437943

and Yanai, K., 2015

(2S,5S,11S,14S,17S)-14-(Carboxymethyl)-17-((S)-2-((S)-1-(glycyl-L-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl)pyrrolidine-2-carboxamido)propanamido)-5-isobutyl-2-isopropyl-11-methyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazanonadecanedioic acid

Clin Kidney J 15:16751684